Record Display for the EPA National Library Catalog
RECORD NUMBER: 47 OF 50
|OLS Field Name||OLS Field Data|
|Main Title||Theoretical foundations of cancer chemotherapy introduced by computer models|
|Author||Jackson, Robert C.|
|Subjects||Cancer--Chemotherapy--Computer simulation ; Pharmacokinetics--Computer simulation ; Cancer cells--Computer simulation ; Antineoplastic Agents--pharmacokinetics ; Computer Simulation ; Models, Chemical ; Neoplasms--drug therapy|
|Collation||xiv, 447 p. : ill. ; 24 cm. + 1 computer disk (5 1/4 in.)|
System requirements for computer disk: IBM PC or compatible; IBM-BASIC, BASICA, or Microsoft GWBASIC (need Microsoft Quick Basic 4.5 to compile source codes). Includes bibliographical references (p. 427-435) and index.
Introduction: models as tools for teaching and research -- Cell cycle effects of drugs -- Anticancer drug selectivity -- Quiescent cells, differentiated cells, and lost cells -- Pharmacokinetic models -- Invasion and metastasis -- Blood-brain barrier -- Cancer treatment and the immune response -- Drug resistance and its implications for treatment strategy -- Growth kinetics of large tumors -- Biochemical basis of anticancer drug selectivity -- Biochemical principles of drug interaction -- Cytokinetics, pharmacokinetics, and inhibition kinetics: a unified model.