Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Rabbit Biotechnology [electronic resource] /
Author Houdebine, Louis-Marie.
Other Authors
Author Title of a Work
Fan, Jianglin.
Publisher Springer Netherlands,
Year Published 2009
Call Number R-RZ
ISBN 9789048122271
Subjects Medicine. ; Biotechnology. ; Genetic engineering. ; Animal genetics.
Internet Access
Description Access URL
Collation VIII, 136 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Improvement of Rabbit Production -- Basic Methods for Experimental Rabbits -- Useful Information for Rabbit Genes, Proteins, and Antibodies -- General Physiology of Rabbits -- Rabbit Transgenesis -- Rabbit as a Model for the Study of Human Diseases -- Transgenic Rabbits to Prepare Pharmaceutical Proteins -- Derivation and Characterization of Rabbit Embryonic Stem Cells: A Review -- Rabbit Cloning -- The European Rabbit Genome. Louis-Marie Houdebine and Jianglin Fan The study of biological functions of proteins and their possible roles in the pathogenesis of human diseases requires more and more relevant animal m- els. Although mice including genetically modified mice offer many possibilities, other non-murine species are absolutely required in some circumstances. Rabbit is one of these species, which has been widely used in biomedical studies. This animal is genetically and physiologically closer to humans including cardiov- cular system and metabolism characteristics. Rabbit is thus more appropriate than mice to study some diseases such as atherosclerosis and lipid metabolism. Because of its larger size, surgery manipulation, bleeding, and turn-over studies are much easier performed in rabbits than in mice. Furthermore, transgenic rabbits can be produced using microinjection and other methods such as lentiviral v- tors. Cloning in rabbits has been proved possible, even though still laborious and time-consuming. Hopefully, functional rabbit ES cell lines will be available in the coming years. Gene deletion or knock-out in rabbits will then become possible.