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OLS Field Name OLS Field Data
Main Title Medaka A Model for Organogenesis, Human Disease, and Evolution / [electronic resource] :
Author Naruse, Kiyoshi.
Other Authors
Author Title of a Work
Tanaka, Minoru.
Takeda, Hiroyuki.
Publisher Springer Japan : Imprint: Springer,
Year Published 2011
Call Number QL1-991
ISBN 9784431926917
Subjects Life sciences. ; Developmental biology. ; Evolution (Biology). ; Animal genetics. ; Transgenic organisms. ; Laboratory animals.
Internet Access
Description Access URL
Collation XVII, 387 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.