Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Nimesulide - Actions and Uses [electronic resource] /
Author Rainsford, K.D.
Publisher Birkhäuser Basel,
Year Published 2005
Call Number RM1-950
ISBN 9783764374105
Subjects Medicine. ; Human physiology. ; Immunology. ; Toxicology. ; Anesthesiology. ; Pain Medicine. ; Rheumatology.
Internet Access
Description Access URL
Collation XVI, 433 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
The discovery, development and novel actions of nimesulide -- Pharmacokinetics of nimesulide -- Pharmaceutical formulations of nimesulide -- Pharmacological properties of nimesulide -- Clinical applications of nimesulide in pain, arthritic conditions and fever -- Adverse reactions and their mechanisms from nimesulide. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.