||Analysis of Multiple Correlated Binary Outcomes: Application to Rodent Teratology Experiments.
Lefkopoulou, M. ;
Moore, D. ;
Ryan., L. ;
||Harvard School of Public Health, Boston, MA. Dept. of Biostatistics. ;Dana-Farber Cancer Inst., Boston, MA. ;Temple Univ., Philadelphia, PA. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC.
Statistical analysis ;
Mathematical models ;
Multivariate analysis ;
Animal pregnancy ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
In a developmental toxicity study, pregnant animals are exposed to the test substance and their offspring are assessed for defects. Often, multiple observations are made on each fetus, in which case the data are doubly nested. In the article, the approach of Liang and Zeger (1986) and Liang (1986) is adapted to yield an analysis, which appropriately allows for the correlation structure. (Copyright (c) American Statistical Association.)