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RECORD NUMBER: 8 OF 11

OLS Field Name OLS Field Data
Main Title NMDA (N-Methyl-D-Aspartate) receptor, antagonist, MK-801, suppresses limbic kindling and kindled seizures /
Author Gilbert, M. E.
CORP Author Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1988
Report Number EPA/600/J-88/338
Stock Number PB89-237457
Additional Subjects Neurochemistry ; Anticonvulsants ; Convulsions ; Dosage ; Amygdala ; Hippocampus ; Rats ; Graphs(Charts) ; Reprints ; Kindling(Neurology) ; N-methyl-D-aspartate ; MK-801 ; Kainate ; Quisqualate ; Neural transmission
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NTIS  PB89-237457 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 12 pages : illustrations ; 28 cm
Abstract
The role of excitatory amino acid neurotransmission in electrical kindling was examined in animals stimulated daily in the amygdala following ip administration of low dosages of MK-801 (0.1 and 0.5 mg/kg). A second experiment evaluated the anticonvulsant properties of MK-801 in rats kindled in the hippocampus and amygdala, and contrasted its efficacy with the antiepileptic agents diazepam, phenobarbital and phenytoin, and the dissociative anesthetics phencyclidine and ketamine. MK-801 (0.5 mg/kg) retarded the development of amygdala kindling and reduced mean afterdischarge (AD) duration over the first 10 stimulation sessions. The low dosage reduced total AD accrued during each kindling stage but failed to alter kindling rate. MK-801 blocked motor seizures induced by stimulation of hippocampal or amygdala kindled foci, but was more effective in reducing seizure severity and AD duration resulting from stimulation of the hippocampal focus. All other drugs tested, with the exception of phenytoin, protected against amygdaloid kindled seizures. It was concluded that excitatory amino acid transmission contributes in an important, but noncritical way to amygdala kindling. (Copyright (c) 1988 Elsevier Science Publishers B.V. (Biomedical Division).)
Notes
Includes bibliographical references. Microfiche.