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RECORD NUMBER: 2 OF 11

OLS Field Name OLS Field Data
Main Title Characterization of Chemical Kindling with the Pesticide Endosulfan.
Author Gilbert, M. E. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA-68-02-4450; EPA/600/J-92/199;
Stock Number PB92-189059
Additional Subjects Kindling(Neurology) ; Organochlorine insecticides ; Endosulfan ; Toxicology ; GABA ; Seizures ; Amygdala ; Rats ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB92-189059 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/22/1992
Collation 10p
Abstract
The present report evaluated the chemical kindling properties of endosulfan. Repeated administration (3X/wk for 21 doses) of endosulfan was found to induce behavioral seizures in rats. Low dosages (5 & 10 mg/kg in corn oil, po) that were without overt toxicity in the majority of animals upon acute administration, began to elicit signs of seizure (myoclonic jerks and clonic seizures) upon repetition. Heightened seizure responsiveness was maintained following a 2-week wash out period, arguing against cumulative toxicity as a mechanism for seizure induction. Electrical kindling induced by once daily stimulation of the amygdala beginning approximately 4 weeks after the final dose of endosulfan, and in excess of 2 weeks, after the challenge dose revealed a significant facilitation in kindling rate. Thus, prior treatment with endosulfan promoted the development of kindled seizures in the absence of further dosing. A history of endosulfan treatment failed to affect threshold for inducing an afterdischarge (AD), but equivocal effects upon the development of AD. Pretreatment with a single high dose of endosulfan 2 weeks prior to electrical kindling was without effect upon development of the kindled response. Chemical kindling with endosulfan may result from the interaction of this pesticide with GABA-mediated neurotransmission in the central nervous system.