||Ca(2+)/Calmodulin-Dependent Protein Phosphorylation Is Not Altered by Amygdaloid Kindling.
Burdette, L. J. ;
O'Callaghan, J. P. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Polyacrylamide gel electrophoresis ;
Electric stimulation ;
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The effects of amygdaloid kindling on Ca(2+)/Calmodulin (CaM)-dependent protein phosphorylation were assessed using one- and two-dimensional gel electrophoresis. In vitro phosphorylation of membrane and cytosol fractions in the presence or absence of Ca(2+)/CaM did not differentiate between kindled and non-kindled amygdaloid tissue. The results suggest that changes in Ca(2+)/CaM-dependent phosphorylation are not related to the mechanism(s) underlying the establishment of an amygdaloid kindled focus.