Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Mode of action of cyclodiene insecticides : the nervous system influenced by toxaphene /
Author Crowder, Larry A.
Other Authors
Author Title of a Work
Lewis, Robert,
Lewis, Robert, Dr.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1980
Report Number EPA-600/1-80-003; EPA-R-804351
Stock Number PB80-186042
OCLC Number 07558297
Subjects Amidines. ; Insecticides. ; Toxaphene.
Additional Subjects Insecticides ; Toxicology ; Pesticides ; Terpenes ; Chlorine aliphatic compounds ; Chlorohydrocarbons ; Halohydrocarbons ; Nervous system ; Metabolism ; Excretion ; Rats ; Insects ; Laboratory animals ; Experimental data ; Physiological effects ; Toxaphene
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-1-80-003 Headquarters Library/Washington,DC 04/27/2012
EJBD  EPA 600-1-80-003 Headquarters Library/Washington,DC 04/23/2014
EJED  EPA-600/1-80-003 OCSPP Chemical Library/Washington,DC 01/01/1988
EKAM  EPA/600/1-80/003 Region 4 Library/Atlanta,GA 05/23/1997
EKCD  EPA-600/1-80-003 CEMM/GEMMD Library/Gulf Breeze,FL 05/29/2018
ELDD  EPA-600/1-80-003 CCTE/GLTED Library/Duluth,MN 05/21/1999
NTIS  PB80-186042 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation xv, 93 pages : illustrations ; 28 cm.
A study was made concerning the mode of action, excretion, metabolism, and behavioral effects of toxaphene and combinations of toxaphene, methyl parathion, and/or chlordimeform in various insects, the mouse and rat. Toxaphene (1) altered ionic movements within the central nervous system of the cockroach, Periplaneta americana, (2) increased levels of cAMP and cGMP in tissues of the cockroach, Leucophaea maderae, and the mouse, and (3) inhibited ATPase enzymes in tissues of P. americana and the mouse. Rat pups perinatally exposed to sublethal doses of toxaphene and methyl parathion showed few significant changes in motor skills, behavior, or learning ability. Postnatal exposure to toxaphene did lead to an impairment of learning ability in adult rats as measured by a simple T-maze. Combining chlordimeform and methyl parathion with 36Cl recovered in feces and the amount deposited in tissues of orally-dosed mice. Combining toxaphene with methyl parathion did not potentiate the toxicity of methyl parathion under laboratory conditions to various hemipteran predators and lepidopterous pests.
"January 1980"--Cover. "Project no. R-804351." "Project officer, Robert Lewis." Includes bibliographical references.