Record Display for the EPA National Library Catalog
RECORD NUMBER: 281 OF 516
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: C-8 Alternatives: Maternal and Developmental Toxicity in the Rat (Preliminary Study by Gavage) with Cover Letter dated 10/16/1992.|
|CORP Author||Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; C-8 alternatives ; Reproduction effects ; Fertility effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Gavage ; CAS No 1868-86-6 ; CAS No 3825-26-1 ; CAS No 4089-61-6 ; CAS No 80010-35-1|
C-9, R-7, TB Sulfate, or TB Sulfonate were administered to rats by gavage at 100, 300, 250, or 500 mg/kg body weight/day, respectively, from Days 6 through 15 of gestation to determine the degree of hazard to the developing conceptus. The dosage of TB Sulfate given was lethal to six of the seven rate tested, and the rat that survived did not yield live fetuses at term. Therefore, its potential hazard to the conceptus was not assessed. The remaining chemicals were tested at levels that were less toxic to the dams. None of the test chemicals were demonstrated to represent a unique hazard to the maintenance of pregnancy or to the developing conceptus.