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RECORD NUMBER: 269 OF 516

OLS Field Name OLS Field Data
Main Title Implementing 'In vitro' Models in the Hazard Identification and Risk Assessment Process.
Author Veronesi, B. ; Claudio, L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Mount Sinai Medical Center, New York. Div. of Environmental and Occupational Medicine.
Publisher 1992
Year Published 1992
Report Number EPA/600/A-92/113;
Stock Number PB92-188796
Additional Subjects Environmental health ; Risk assessment ; Health hazards ; Toxic substances ; In vitro analysis ; Species specificity ; Dose-response relationships ; Animal testing alternatives ; Structure-activity relationships ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-188796 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/22/1992
Collation 28p
Abstract
Concerns about the use of laboratory animals in biomedical research and testing and the relevance of animal data to the human condition are not new issues. Toxicologists have long been aware of the difficulties in interpreting and extrapolating data derived from animals to humans because of species-specific susceptibilities to toxic effects and differences in exposure magnitudes. Such difficulties are compounded by the possibility that data generated in young, healthy, single strain test animals may not apply to a human population that is old, diseased, malnourished, or diverse in its genetic makeup. Since the human population is more heterogeneous than experimental animal strains, it may be sensitive to a wider range of doses than animals. The chapter describes some of the above issues, discusses the potential of current in vitro neurotoxicity tests to address the needs of risk assessment and hazard identification, the advantages and limitations of such models, the scientific validation process, and finally, future directions that might be pursued to encourage their deployment in risk assessment.