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RECORD NUMBER: 36 OF 120

OLS Field Name OLS Field Data
Main Title Effect of Alcohol on Behavioral and Autonomic Thermoregulation in Mice.
Author Gordon, C. J. ; Stead, A. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Stock Number PB88-171111
Additional Subjects Toxicology ; Alcohols ; Behavior ; Mice ; Laboratory animals ; Reprints ; Thermoregulation
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-171111 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Abstract
Male, BALB/c mice were injected intraperitoneally with ethyl alcohol (ethanol) in dosages of 0, 0.03, 0.1, 0.3, 1.0, or 3.0 g/kg and then placed in a temperature gradient which permitted the measurement of preferred ambient temperature (Ta). The 3 g/kg dosage of ethanol resulted in a slight lowering of the preferred Ta during the first 30 min of placement in the gradient. However, there was no overall statistically significant effect of alcohol dosage on preferred Ta. In another experiment, BALB/c mice were treated with the aforementioned thanol dosages while metabolic rate (MR), evaporative water loss (EWL), and colonic temperature were measured 60 min post-injection at Ta's of 20, 30, and 35 C a dosage of 3 g/kg caused a significant decrease in MR, EWL, and colonic temperature. At a Ta of 30 C this same dosage caused significant reduction in colonic temperature, however; at Ta of 35 C ethanol had no effect on these parameters. In spite of the significant decrease in colonic temperature at a Ta of 30 C, which approximates the normal preferred Ta, the behavioral thermal preference was marginally affected. It is not clear whether or not ethanol injection results in a decrease in the set-point body temperature.