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OLS Field Name OLS Field Data

Main Title Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats.

Author Rezvani, A. H. ; Garges, P. L. ; Miller, D. B. ; Gordon, C. J. ;

CORP Author Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill.

Publisher c1992

Year Published 1992

Report Number EPA/600/J-92/424;

Stock Number PB93-141232

Additional Subjects Alcohol drinking ; Amphetamines ; Serotonin ; Rats ; Water consumption ; Body temperature ; Drinking behavior ; Alcoholism ; Reprints ; Methylenedioxymethamphetamine

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB93-141232	Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.		06/12/1993

Collation 10p

Abstract

Alcohol preference and manifestation of alcoholism are thought by many to be associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were performed to determine the effect of acute and sub-chronic administration (s.c.) of + or - 3,4-methylenedioxymethamphetamine (MDMA), an amphetamine analog which stimulates 5-HT release, on alcohol preference in two strains of alcohol preferring rats, the Fawn-Hooded (FH) and alcohol preferring (P) rats. Our results show that a single administration of 5.0 mg/kg MDMA significantly decreased ethanol intake in both FH and P rats and increased water intake. Sub-chronic administration of 5.0 mg/kg MDMA for three consecutive days significantly attenuated alcohol intake in both strains.

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