Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title U.S. Environmental Protection Agency's Inhalation RFD Methodology: Risk Assessment for Air Toxics.
Author Jarabek, A. M. ; Menache, M. G. ; Overton, J. H. ; Dourson, M. L. ; Miller, F. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-90/357;
Stock Number PB91-163717
Additional Subjects Air pollution effects(Humans) ; Risk assessment ; Health hazards ; Respiration ; Neoplasms ; Dose-response relationships ; Reprints ; Reference doses
Library Call Number Additional Info Location Last
NTIS  PB91-163717 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 25p
The U.S. Environmental Protection Agency (U.S. EPA) has advocated the establishment of general and scientific guidelines for the evaluation of toxicological data and their use in deriving benchmark values to protect exposed populations from adverse health effects. The Agency's reference dose (RfD) methodology for deriving benchmark values for noncancer toxicity originally addressed risk assessment of oral exposures. The paper presents a brief background on the development of the inhalation reference dose (RFDi) methodology, including concepts and issues related to addressing the dynamics of the respiratory system as the portal of entry. Different dosimetric adjustments are described that were incorporated into the methodology to account for the nature of the inhaled agent (particle or gas) and the site of the observed toxic effects (respiratory or extrarespiratory). Impacts of these adjustments on the extrapolation of toxicity data of inhaled agents for human health risk assessment and future research directions are also discussed. (Copyright (c) 1989 Princeton Scientific Publishing Co., Inc.)