||Dose-Effects Functions for Carboxyhemoglobin and Behavior.
Benignus, V. A. ;
Muller, K. E. ;
Malott, C. M. ;
||North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch.;Army Medical Research and Development Command, Fort Detrick, MD.
Carbon monoxide ;
Laboratory animals ;
Critical flicker fusion ;
Dark adaptation ;
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Literature on dose-effects functions of carboxyhemoglobin (COHb) and human behavior is internally inconsistent. The present review and analysis of published data was undertaken to attempt to reduce uncertainty about COHb dose effects functions. Dose-effects data from animal operant behavior studies were reviewed and dose-effects functions were fitted. The curves indicated small effects (if any) for COHb levels less than ca. 20%. As COHb increased further, the slope of the function became progressively steeper. Review of the human dose-effects function publications for COHb and behavior revealed that apparently, effects of COHb on behavior in man are small or absent below ca. 20% (essentially the highest COHb level for which dose-effects data are available). A dose-effects curve was fitted to the human data from one study (7) and compared to the laboratory animal curves. Extrapolation of the human curve was used infer that the dose-effects curves for humans and laboratory animals were of similar form.