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RECORD NUMBER: 47 OF 3451

OLS Field Name OLS Field Data
Main Title Acute Inhalation Toxicity in Rats Using Dibutylamine: Four Hour Exposure.
CORP Author Huntingdon Research Centre PLC (England).; Pennwalt Corp., King of Prussia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-870000540
Stock Number OTS0513618
Additional Subjects Toxicology ; Health effects ; Dibutylamine (111-92-2) ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 111-92-2
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NTIS  OTS0513618 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 42p
Abstract
Acute inhalation toxicity was evaluated in groups of 5 male and 5 female Sprague-Dawley albino rats exposed to dibutylamine at actual concentrations of 0.76, 1.08, 1.18, 1.39 or 3.91 mg/l of air for 4 hours. Mortality was observed in 2 animals in the 0.76 mg/l dose group, 4 in the 1.18 mg/l dose group, and all 10 in both the 1.39 and 3.91 mg/l dose groups. The LC50 value was calculated to be 1.15 mg/l (standard error of 0.095 mg/l) by the log probit method of Miller and Tainter. Clinical observations included excessive salivation, lacrimation, gasping, convulsions, abnormal breathing, ataxia, lethargy, rales, and staining of the urogenital area. Gross necropsy revealed lung congestion in decedents.