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RECORD NUMBER: 45 OF 3451

OLS Field Name OLS Field Data
Main Title Acute Inhalation Toxicity Evaluation in Rats with Zinc Omadine Fps (Final Report) with Cover Letter Dated 01/15/1991.
CORP Author International Research and Development Corp., Mattawan, MI.; Olin Corp., Baraboo, WI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 89-910000145
Stock Number OTS0527753-1
Additional Subjects Toxicology ; Health effects ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 13463-41-7
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NTIS  OTS0527753-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 91p
Abstract
Zinc omadine (13463-41-7) was evaluated for acute inhalation toxicity in six groups of 5 male and 5 female Sprague-Dawley albino rats exposed to the test material at concentrations of 0.054, 0.14, 0.16, 0.82, 1.4 and 1.5 mg/L for 4 hours. The use of controls was not specified. The animals were observed for 14-days post-exposure. Mortality was observed at all exposure levels, with deaths occurring most frequently on day 1 after exposure. No deaths occurred past day 3 post-exposure. Clinical observations on the day of exposure at all concentration levels included prostration, gasping, labored breathing, rales, trembling and hunched posture. Clinical signs after exposure included urine stained abdomen, labored breathing, rales, lacrimation and red material around the nose/eyes/mouth. Exposure related abnormalities at necropsy were limited to the respiratory tract and were characterized by congestion. Histopathological examination was not specified. The LC50 for males and females combined was 0.14 (0.1-0.2) mg/L.