Record Display for the EPA National Library Catalog

RECORD NUMBER: 190 OF 3451

OLS Field Name OLS Field Data
Main Title Calidria Asbestos-Resin Grade Rg 244 Tracheal Insufflation of Rat Lungs with Interpretation of Pathology after 30, 60, 90, and 120 days with Cover Letter.
CORP Author Union Carbide Corp., Oak Ridge, TN. Office of Health, Safety, and Environmental Affairs.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1983
Report Number 878210814
Stock Number OTS0206063
Additional Subjects Toxicity ; Health effects ; Asbestos(1332-21-4) ; Acute toxicity ; Mammals ; Rats ; Inhalation ; Intratracheal instillation ; CAS No 1332-21-4
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NTIS  OTS0206063 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 04/28/2010
Collation 26p
Abstract
Acute toxicity was determined in 28 male albino Harlan Wistar rats receiving resin grade RG 244 UCC calidria asbestos as a 1% (w/v) suspension in 0.85% saline by tracheal instillation. A total of 1 ml of the solution was received by 13 rats and 0.5 ml was received by 15 rats. There were no mortalities or clinical observations reported. Gross and microhistopathological examinations were made on the lungs, liver, kidneys, heart, spleen, adrenal, thyroid, parathyroid, trachea and esophagus. Histopathological examinations of the lungs at 30 days post-testing revealed granulation tissue, thickened stroma and an accumulation of giant cells. Examination after 60 days revealed inflammation and ingrowth of connective tissue causing blockage of a terminal bronchus, atelectasis (collapse) of lung lobes and fibrotic foreign body nodules. After 90 days, examination revealed chronic foreign body pneumonia, emphysema, chronic inflammatory cell foci, dilated bronchioles and lung hemorrhage. Examination at 180 days revealed decrease in the normal lung tissue, pink hyalin material and bluish homogeneous material. Document includes: The Fibrogenic Potential of Asbestos Products Via Intraperitoneal Injection in Guinea Pigs, Rats, and Rabbits and by the Intratracheal Route in the Rat.