Record Display for the EPA National Library Catalog

RECORD NUMBER: 167 OF 3451

OLS Field Name OLS Field Data
Main Title Approximate Lethal Dose of Hfc-152a in Rats with Cover Letter (Sanitized).
CORP Author ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1990
Report Number 86-910000029S
Stock Number OTS0530083
Additional Subjects Toxicology ; Health effects ; 1 ; 1-difluoroethane (75-37-6) ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 75-37-6
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NTIS  OTS0530083 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 10p
Abstract
1,1-Difluoroethane (75-37-6) was evaluated for acute oral toxicity in 6 male Crl: CD BR rats administered doses of 200, 300, 450, 670, 1000, and 1500 mg/kg of by gavage. The use of controls was not specified. The observation period was 14 days post-treatment. No mortalities occurred. Clinical signs immediately after dosing in all rats included abdominal distension and lethargy. Clinical signs seen with 48 hours post-dosing included high carriage, wet and yellow stained perineums and diarrhea. Necropsy and a histopathological examination were not specified. The LD50 for 1,1-difluoroethane is greater than 1500 mg/kg, and was considered to be slightly toxic when administered as a single oral dose in rats.