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RECORD NUMBER: 28 OF 158

OLS Field Name OLS Field Data
Main Title Acute Toxicological Properties and Industrial Handling Hazards of Cresol (Ortho, Meta, Para Isomers) Sample Preference.
CORP Author Dow Chemical Co., Midland, MI.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 11 Jan 1978
Year Published 1978
Report Number 878211373;
Stock Number OTS-0206146
Additional Subjects Toxicity ; Cresols ; Industrial handling ; Toxicology ; Properties ; Rabbits ; Skin irritation ; Eye irritation ; Lethal doses ; Meta cresol ; Ortho cresol ; Para cresol ; CAS No. 108-39-4 ; CAS No. 95-48-7 ; CAS No. 106-44-5 ; Acute oral lethality ; Acute inhalation toxicity
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Status
NTIS  OTS-0206146 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/29/2008
Collation 14p
Abstract
A sample of cresol was submitted to the Comparative Toxicology Research Laboratory for evaluation of acute oral lethality, acute inhalation toxicity, eye irritation properties, skin irritation properties by the method of testing primary irritant substances in accordance with the procedure outlined La the Federal Register, Volume 38, Number 187, Part II, Section 1500.41, and for definition of industrial handling hazards involving acute exposures. A member of the Industrial Health Team (Toxicologist, Industrial Hygienist, and/or Industrial Physician) should be consulted for recommendation of additional safety evaluations or handling procedures which may be needed to support manufacture and/or use of this test material. The acute oral lethality of the test material is low. The acute oral LD50 value determined in 24 albino rats was found to be between 1.0 g/kg and 2.0 g/kg of body weight. The probability that internal injury might result from acute ingestion of amounts of the test material one might encounter incidental to industrial handling is minimal. The test material had an extremely severe effect upon the eyes of an albino rabbit. Direct contact with this material resulted in tissue destruction leading to permanent impairment of vision.