Record Display for the EPA National Library Catalog

RECORD NUMBER: 21 OF 34

Main Title Initial Submission: Letter from Dupont Chemical to USEPA regarding Toxicity Studies of Acrolein with Cover Letter dated 10/15/1992.
CORP Author Union Carbide Corp., Danbury, CT.; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11540
Stock Number OTS0571470
Additional Subjects Toxicology ; Health effects ; Acrolein ; Acute toxicity ; Mammals ; Rats ; Oral ; Gavage ; Rabbits ; Dermal ; Inhalation ; Primary dermal irritation ; Primary eye irritation ; CAS No 107-02-8
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0571470 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract
In both studies, beagle dogs were administered dietary concentrations of 2,000, 5,000 or 20,000 ppm. Those dogs administered the test material encapsulated in silica were found to exhibit reduced hemoglobin and hematocrit values, as well as abnormal erythroyote morphology. Histopathology revealed dose-related renal lesions. Chromium and lead levels were elevated in the liver, kidneys, bone and brain. In the other study, treatment-related effects also included a decrease in henoglobin and hematocrit values, as well as abnormal erythrocyte morphology. Histopathology revealed focal tubular nephrosis. Microscopic examination of brain and spinal cord revealed characteristic, lead-induced lesions in 4 of 8 dogs at the 20,000 ppm dose level. The content and chromium of the liver, kidney, and brain tissue were increased in all dogs.