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RECORD NUMBER: 47 OF 52

OLS Field Name OLS Field Data
Main Title Trimethyltin Disrupts Acoustic Startle Responding in Adult Rats.
Author Ruppert, P. H. ; Dean, K. F. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/115;
Stock Number PB85-110005
Additional Subjects Acoustics ; Toxicology ; Behavior ; Rats ; Laboratory animals ; Reprints ; Trimethyltin ; TMT
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-110005 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract
Trimethyltin (TMT) is a limbic-system toxicant which also produces sensory dysfunction in adult animals. In the present experiment, the authors examined the effects of TMT on the acoustic startle response. Adult male, Long-Evans rats (N=12/dose) received a single i.p. injection of either 0, 4.0, 5.0 or 6.0 mg/kg TMT hydroxide as the base. The number of responses, latency and peak amplitude of the startle response to a 13 kHz, 120 dB tone were measured 2 h, 2 weeks, and 4 weeks after dosing. For each test session, 10 stimuli were presented at each of three background noise levels (50, 65 and 80 dB). By 2 h after dosing, the number of response and response amplitude were decreased following 4.0-6.0 mg/kg TMT; these treatment effects persisted through 4 weeks after dosing. Increases in latency were also seen following all dosages of TMT. These data suggest that TMT produces disruption of function within the acoustic-startle pathway.