This innovative technology report provides an overview of innovative acid mine drainage treatment technologies that employ sulfate-reducing bacteria (SRB). Through a synthesis of research and case studies of SRB treatment at coal and hardrock mine sites, it will present lessons for further application of this technology. The target audience for this paper includes owners, operators, contractors, regulators, and stakeholders with an interest in acid mine drainage remediation. Though this work focuses on abandoned hardrock mine sites generating acid drainage, aspects of these technologies may apply to active mine sites, coal mines, and other industrial operations that generate acidic and metallic discharges. These innovative remediation technologies are presented with the view of promoting more effective, efficient clean-up, or facilitating remediation of sites that could not practicably be treated with other technologies.