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RECORD NUMBER: 17 OF 190

OLS Field Name OLS Field Data
Main Title Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver.
Author Herren-Freund, S. L. ; Pereira, M. A. ; Khoury, M. D. ; Olson, G. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pathology Associates, Inc., Cincinnati, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-68-03-3215; EPA/600/J-87/275;
Stock Number PB88-185541
Additional Subjects Acetic acid ; Liver neoplasms ; Mice ; Adenoma ; Carcinogens ; Phenobarbital ; Drugs ; Toxicity ; Toxicology ; Potable water ; Contaminants ; Water pollution ; Reprints ; Trichloroacetic acid ; Trichloroethylene ; Dichloroacetate ; Drug synergism ; Ethylnitrosourea
Holdings
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Status
NTIS  PB88-185541 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 9p
Abstract
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when given by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic acid (DCA) as a minor metabolite. These chlorinated acetic acids have not been shown to be genotoxic; although, they have been shown to induce peroxisome proliferation. Therefore, the authors determined the ability of TCE, TCA, or DCA to act as tumor promoters in mouse liver. Therefore our results demonstrate that DCA and TCA are hepatocarcinogens in B6C3F1 mice although there has been no previous evidence of their geonotoxicity. (Copyright (c) 1987 by Academic Press, Inc.)