Record Display for the EPA National Library Catalog
RECORD NUMBER: 20 OF 23| Main Title | Support: TSCA Health and Safety Study Cover Sheet with Summary of Combined Study on Chronic Toxicity and Carcinogenicity in Wistar Rats (Dietary Administered for Two Years) of AMS 21618 (Confidential), dated 12/10/2001 (Sanitized). | |||||||||||
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| CORP Author | Bayer A.G., Dormagen (Germany, F.R.).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 2002 | |||||||||||
| Report Number | 8EHQ-0102-14945S | |||||||||||
| Stock Number | OTS0560044-1 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Toxic substances ; AMS 21618 | |||||||||||
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| Collation | 6p | |||||||||||
| Abstract | AMS 21618 was administered orally via the diet to Wistar rats (50 males and 50 females per dose) at doses of 0, 40, 100, 1000, and 5000 ppm for males and 0,100, 500, 2500, and 12500 ppm for females for a period of up to 753 days (108 weeks). In addition, a group of 10 male and 10 female Wistar rats per dose group were treated likewise with AMS 21618 and sacrificed after a treatment period of about 1 year. Averaged over the study period, the mean daily test compound intake was 2.1, 5.2, 53.0, and 271.9 mg/kg for males and was 6.9, 35.2, 181.3, 1083.2 mg/kg for females. |