||Initial Submission: Letter from (Confidential Source) to USEPA Reporting Results in Acute Dermal Toxicity Test of 2,6-Dichloroaniline in Rats, dated 08/06/1999. (Sanitized).
||; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Laboratory animals ;
Toxic substances ;
Acute toxicity ;
Laboratory tests ;
Risk assessment ;
Acute dermal toxicity
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Five male and female Fischer 344 rats were given either a single dermal application to provide a dose level of 2000, 2500 or 5000 mg/kg or a subcutaneous injection to provide a dose level of 2000 or 2500 mg/kg of the study compound dissolved in DMSO. Clinical observations indicate that at 5000 mg/kg dermal application whole body twitching was observed in the one surviving female rat and three of the five male rats were laterally recumbent with whol body twitching a the above dermal level.