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OLS Field Name OLS Field Data
Main Title Cutaneous Carcinogenicity Study with Mice on the Diglycidyl Ether of 1,4-butane Diol with Attachments and Cover Letter dated 09/28/1987.
CORP Author CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1987
Report Number 86-880000066
Stock Number OTS0513957
Additional Subjects Toxicology ; Health effects ; 1 ; 4-butane Diol (2425-79-8) ; Chronic Toxicity ; Carcinogenicity ; Mammals ; Mice ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 2425-79-8
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NTIS  OTS0513957 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 53p
Abstract
Dermal carcinogenicity was evaluated in groups of male and female CF1 mice (50/sex/group) receiving applications (volume not reported) of 0.05% or 0.2% (based on preliminary studies) 1,4-butanediol diglycidyl ether in acetone twice weekly to the dorsal skin for 103 weeks. Of all animals in both dose groups, 5 animals developed 6 neoplasms of the skin and subcutis; 1 control animal developed a tumor. A transient irritant reaction was observed in 37 animals with no thickening of the epidermis. A statistically significant increase in neoplasms of the treated skin was not observed.