Record Display for the EPA National Library Catalog

RECORD NUMBER: 20 OF 2499

OLS Field Name OLS Field Data
Main Title 2-chlorotoluene Metabolism by Rats with Cover Letter dated 01/14/1983.
CORP Author Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1983
Report Number 40-8335077
Stock Number OTS0507452
Additional Subjects Toxicology ; Health effects ; 2-chlorotoluene ; Pharmaco Kinetics ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 95-49-8
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NTIS  OTS0507452 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 21p
Abstract
Absorption and metabolism of 2-chlorotoluene was examined in four female and four male Sprague-Dawley albino rats administered a single, oral 1 mg/kg bw dose of (U-ring-14C)2-chlorotoluene by gavage. Following administration, 2-chlorotoluene was rapidly absorbed; near complete elimination of the dose occurred within four days. No significant sex-related differences in metabolism of the test compound were found between males and females. A total of 85-92%, 5-8%, and 1-4% of the applied 14C were excreted in the urine, feces, and expired air, respectively. The primary urinary metabolites were 2-chlorobenzoic acid, a glucuronide of 2- chlorobenzyl alcohol, and a mercapturic acid, representing 20-23, 35-42, and 21-28% of the urinary 14C, respectively.