Record Display for the EPA National Library Catalog

RECORD NUMBER: 13 OF 2499

OLS Field Name OLS Field Data
Main Title 2 Phenoxyethanol: Two-week Dermal Probe Study in Female New Zealand White Rabbits to Assess Hematological Effects with Cover Letter.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1985
Report Number 878216053
Stock Number OTS0206805
Additional Subjects Toxicology ; Health effects ; 2-phenoxyethanol (122-99-6) ; Subchronic Toxicity ; Mammals ; Rabbits ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 122-99-6
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Status
NTIS  OTS0206805 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 22p
Abstract
Subchronic toxicity was evaluated in groups of 10 female New Zealand White rabbits exposed to 2-phenoxyethanol for 14 consecutive days at a level of 0 or 0.91 ml/kg/day as an occluded dose to clipped, intact skin. Mortality was observed in 7 rabbits by day 8 of the experiment. Clinical observations included discoloration of the skin at the test site. Necropsy revealed hemoglobinuria; pale livers; dark kidneys and spleens; decreased hemoglobin, PCV and RBC values; increased erythrocyte indices, nucleated RBC's, leukocytes and erythrocytes; and regenerative hemolytic anemia due to intravascular hemolysis of RBC's.