Abstract |
Groups of five male rats were administered 2-11 doses of the test compound by gavage at 10, 100 or 300 mg/kg over 2-15 days. Animals in the high-dose group either died or were euthanatized in poor condition after two doses. Abnormalities observed in the high-dose group included: dehydration; weakness; decreases in white blood cell count and glucose; increases in aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase, and urea nitrogen; and an increase in relative liver and kidney weights. A variety of gross and histopathologic changes were observed in the moribund animals of the high-dose group. Abnormalities in the mid-dose group were decreased feed intake and minor to moderate eosinophilic cytoplasmic changes in the liver. No treatment related effects were observed in the low-dose group. The test compound has been sold as a pure chemical in volumes of 0-7.5 kg/year; it is not currently sold. |