||Human Rotavirus Studies in Volunteers: Determination of Infectious Dose and Serological Response to Infection.
Ward, R. L. ;
Bernstein, D. I. ;
Young, E. C. ;
Sherwood, J. R. ;
Knowlton, D. R. ;
||James N. Gamble Inst. of Medical Research, Cincinnati, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Medical research ;
Infectious diseases ;
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An unpassaged, safety-tested strain of human rotavirus, obtained from a stool specimen of a hospitalized child (CJN), was administered orally to 62 adult volunteers to determine the dose required to produce infection with or without illness. Seventeen of 30 infected subjects became ill with doses equivalent to that required for infection. The CJN virus was shown to be serotypically related to the Wa strain of human rotavirus (serotype-1) but unrelated to representatives of the other 3 established human serotypes. Infected subjects, however, experienced nearly equivalent rises in serum neutralizing antibody titer to representatives of all 4 human serotypes as well as the CJN virus. It appeared, therefore, that the CJN virus shared neutralization epitopes with viruses belonging to each of these serotypes. (Copyright (c) 1986 by the University of Chicago.)