Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Hepatic Polyamines and Related Enzymes Following Chlordecone-Potentiated Carbon Tetrachloride Toxicity in Rats.
Author Rao, S. B. ; Young, R. A. ; Mehendale., H. M. ;
CORP Author Mississippi Univ. Medical Center, Jackson. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.;Harry G. Armstrong Aerospace Medical Research Lab., Wright-Patterson AFB, OH.
Publisher c1989
Year Published 1989
Report Number EPA-R-814053; EPA/600/J-89/466;
Stock Number PB91-109579
Additional Subjects Carbon tetrachloride ; Liver ; Toxicity ; Enzymes ; Polyamines ; Body weight ; Metabolism ; Reprints ; Chlordecone ; Chemical stimulation ; Liver regeneration
Library Call Number Additional Info Location Last
NTIS  PB91-109579 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 11p
Previous work has shown that dietary exposure of rats to non-toxic levels of chlordecone (10 parts per million) for 15 days and a subsequent intraperitoneal injection of a low, non-toxic dose of CCl4 results in a dramatic potentiation of hepatotoxicity and lethality greater than that observed after a high dose (2.5 ml/kg body weight) of CCl4 alone. This remarkable amplification of CCl4 toxicity is due to the failure of the hepatocellular regenerative and hepatolobular repair mechanisms. Polyamines are known to be important for liver regeneration and the progressive phase of hepatotoxicity and lethality observed after the combination treatment might be related to the extent of suppressed polyamine metabolism in the liver. In the study polyamines and related enzymes were estimated in the livers of rats treated with either chlordecone and CCl4 or CCl4 alone.