Workers in pesticide formulation plants are often exposed to relatively high levels of pesticide compounds. Since most chemical pesticides have at least some degree of toxidity to man, it is important that all workers, as well as management, be aware of any potential hazard that may accompany exposure to such compounds. Experience has shown that if proper precautionary measures are observed, workers can safely handle even the more toxic compounds. Although pesticides cause illnesses and even deaths each year, many of these cases are a result of carelessness or accident. Proper education as well as close supervision of workers may prevent some accidents and greatly reduce the number of illnesses resulting from carelessness. The main purpose of this chapter is to discuss some of the problems related to exposure of workers in formulation plants, to indicate various ways that unnecessary exposure to pesticides may occur and to point out certain precautions to prevent such exposure.