Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Synthesis of Haptens and Potential Radioligands and Development of Antibodies to Insect Growth Regulators Diflubenzuron and BAY SIR 8514.
Author Wie, S. I. ; Sylwester, A. P. ; Wing, K. D. ; Hammock, B. D. ;
CORP Author California Univ., Davis.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-R-806447; EPA/600/J-82/468;
Stock Number PB86-230315
Additional Subjects Chemical analysis ; Growth regulators ; Insects ; Anilines ; Nitrogen ; Chemical reactions ; Bromine organic compounds ; Butyrates ; Esters ; Ethyl acetate ; Metabolism ; Antibodies ; Reprints ; Diflubenzuron ; Bay Sir 8514 ; Haptens
Library Call Number Additional Info Location Last
NTIS  PB86-230315 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
A variety of synthetic approaches were undertaken, leading to potential haptens and radioligands for the benzoylphenylurea insect growth regulators diflubenzuron and BAY SIR 8514. One successful approach involved derivatization of the aniline nitrogen by ethyl 4-bromobutyrate followed by reaction with an appropriate isocyanate and cleavage of the ethyl ester to yield a free carboxypropyl 'handle'. Useful haptens were also synthesized by using a 3'-phenolic metabolite of diflubenzuron as well as acetate and amine functionalities in the 4' position while the N-sulfenyl bond proved too unstable for use as an antigen.