||Environmental Tobacco Smoke: Mutagenic Emission Rates and Their Relationship to Other Emission Factors.
Lewtas, J. ;
Williams, K. ;
Lofroth, G. ;
Hammond, K. ;
Leaderer, B. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Nordic School of Public Health, Goeteborg (Sweden). ;Massachusetts Univ. Medical School, Worcester. ;Yale Univ., New Haven, CT. School of Medicine.
Hazardous materials ;
Air pollution ;
Tobacco smoke pollution ;
Environmental pollution ;
ETS(Environmental Tobacco Smoke)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The objective of this study was to evaluate the emission rates and exposure concentrations of mutagens, nicotine, and particles from cigarettes. Studies were conducted under controlled laboratory and chamber conditions as well as in personal residences. The mutagenicity of environmental tobacco smoke (ETS) was evaluated in three bioassays using two strains of Salmonella typhimurium. Strain TA98 was used in the standard plate-incorporation and microsuspension histidine reversion assays; and strain TM677 in a microsuspension forward mutation assay. The mutagenicity, expressed either per Ug particle or per Ug nicotine, appeared to be a relatively constant factor that did not vary significantly between various cigarette brands. These data are being used to model the emissions of mutagens to predict mutagenic exposure concentrations under various conditions.