Record Display for the EPA National Library Catalog

RECORD NUMBER: 12 OF 31

OLS Field Name OLS Field Data
Main Title Enhancement of Benzo(a)Pyrene Mutagenicity by Chrysotile Asbestos in Rat Liver Epithelial Cells.
Author Reiss, B. ; Tong, C. ; Telang, S. ; Williams, G. M. ;
CORP Author American Health Foundation, Valhalla, NY. Naylor Dana Inst. for Disease Prevention.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-803998.; EPA-600/J-83-163;
Stock Number PB84-170919
Additional Subjects Toxicology ; Asbestos ; Rats ; Liver ; Epithelium ; Cells(Biology) ; Exposure ; Reprints ; Benzopyrene ; Mutagenesis
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-170919 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
The co-mutagenicity of chrysotile asbestos and benzo(a)pyrene (B(a)P) was studied in adult rat liver (ARL-18) epithelial cells. Exposure to chrysotile alone did not increase the mutant incidence whereas B(a)P was mutagenic. Simultaneous exposure of the cells to chrysotile and B(a)P resulted in an enhanced mutant recovery compared to exposure to either of these substances alone. However, chrysotile did not enhance the mutagenicity of the carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine.