||Effect of Methyl Linoleate Hydroperoxide (MLHP), A Possible Toxic Intermediate of Ozone, on Human Normal and Glucose-6-Phosphate Dehydrogenase (G-6-PD) Deficient Erythrocytes.
Williams, P. S. ;
Calabrese, E. J. ;
Moore, G. S. ;
||Massachusetts Univ., Amherst. Dept. of Public Health.;Health Effects Research Lab., Research Triangle Park, NC.
In vitro analysis ;
Air pollution ;
Chemical reactions ;
Public health ;
Chemical reaction mechanisms ;
Air pollution effects(Humans) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Erythrocytes of both normal and G-6-PD deficient humans responded in a dose-dependent manner to the oxidant stress of MLHP as measured by decreases in G-6-PD activity, increases in methemoglobin (METHB) levels and decreases in reduced glutahione (GSH). The G-6-PD deficient erythrocytes displayed a markedly enhanced sensitivity to MLPH induced decreases in G-6-PD activity and METHB increases while being less sensitive than normal erythrocytes to changes in GSH levels. (Copyright (c) 1983 by Marcel Dekker, Inc.)