||Teratogenic Effects of Benomyl in the Wistar Rat and CD-1 Mouse, with Emphasis on the Route of Administration.
Kavlock, Robert J. ;
Chernoff, Neil ;
Gray, Jr., L. Earl ;
Gray, Jacqueline A. ;
Whitehouse, Douglas ;
||Health Effects Research Lab., Research Triangle Park, NC.
Environmental surveys ;
Benzimidazole carbamic acid/methyl-(butylcarbarmoy)
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Benomyl, a systemic fungicide whose molecular basis of action is inhibition of tubulin polymerization, was administered during organogenesis via the dietary and gavage routes to pregnant Wistar rats, and via the gavage route to pregnant CD-1 mice. Benomyl was fetotoxic and teratogenic in both species via the po route of administration, producing a broad spectrum of malformations at a dose of 62.5 mg/kg/day in the rat and 100 mg/kg/day in the mouse.