Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 3

OLS Field Name OLS Field Data
Main Title Teratogenic Effects of Benomyl in the Wistar Rat and CD-1 Mouse, with Emphasis on the Route of Administration.
Author Kavlock, Robert J. ; Chernoff, Neil ; Gray, Jr., L. Earl ; Gray, Jacqueline A. ; Whitehouse, Douglas ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-170;
Stock Number PB82-247529
Additional Subjects Pesticides ; Fungicides ; Ingestion(Biology) ; Environmental surveys ; Carbamates ; Reprints ; Benomyl ; Teratogenesis ; Benzimidazole carbamic acid/methyl-(butylcarbarmoy)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-247529 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 13p
Abstract
Benomyl, a systemic fungicide whose molecular basis of action is inhibition of tubulin polymerization, was administered during organogenesis via the dietary and gavage routes to pregnant Wistar rats, and via the gavage route to pregnant CD-1 mice. Benomyl was fetotoxic and teratogenic in both species via the po route of administration, producing a broad spectrum of malformations at a dose of 62.5 mg/kg/day in the rat and 100 mg/kg/day in the mouse.