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OLS Field Name OLS Field Data
Main Title Behavioral Alterations Due to Diesel Exhaust Exposure.
Author Laurie, R. Dana ; Boyes, William K. ; Wessendarp, Thomas ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-600/J-81-606;
Stock Number PB83-157081
Additional Subjects Toxicology ; Exhaust gases ; Behavior ; Rats ; Laboratory animals ; Exposure ; Reprints ; Diesel engine exhaust ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-157081 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
Several experiments examining the effects of diesel exhaust on the behavior of rats are reported. Animals were exposed either as adults or neonates. The spontaneous locomotor activity (SLA), measured in standard running wheel cages, of adult rats exposed for 8 h/day, 7 days/week was significantly less than that of controls. Experiments involving diesel exhaust exposure to neonatal rats indicated that adults rats, exposed to diesel exhaust during their neonatal lives, were significantly less active as measured by SLA. Adult rats, exposed to 20 h diesel per day as neonates, were placed in skinner boxes after the SLA experiment described above had been completed. The exhaust exposed animals showed significantly decreased acquisition of a food reinforce bar pressing task. All animals that learned this task extinguished at the same rate. The results of the neonatal diesel exhaust experiments support the hypothesis that diesel exhaust exposure during development of an organism can lead to behavioral differences in adulthood.