Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Carbon Tetrachloride Treatment on Urine Flow Rate of the Rainbow Trout, 'Salmo gairdneri'.
Author Pfeifer, K. F. ; Weber, L. J. ;
CORP Author Oregon State Univ., Newport. Marine Science Center.;Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-R-803090; EPA-600/J-80-435;
Stock Number PB84-117431
Additional Subjects Toxicology ; Carbon tetrachloride ; Chlorine organic compounds ; Urine ; Concentration(Composition) ; Fishes ; Reprints ; Water pollution effects(Animals) ; Rainbow trout ; Salmo gairdneri
Library Call Number Additional Info Location Last
NTIS  PB84-117431 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 7p
Urine flow rate (UFR) of rainbow trout was measured as an assessment of water balance after treatment with a single ip dose of CC14 (2.0 ml/kg). CC14 produced an oliguria or anuria as early as 1 hr post-treatment and a significant reduction in the 24-hr urine output. UFR for control fish appeared to follow a diurnal pattern. Additionally, CC14-treated fish had a significant increase in relative wet body weight that was negatively correlated to UFR. The rainbow trout normally excretes a hypoosmotic urine; therefore, an increase in urine osmolality and a slight proteinuria further suggested that treated fish had suffered an alteration in renal homeostasis. Histological examination of kidney tissue at 24 hr post-treatment revealed early, localized pathological changes; however, extensive morphological damage was absent. The early oliguria and the lack of demonstrable renal histopathological changes in CC14-treated rainbow trout suggest that the reduction in UFR was not the result of a direct toxic effect on the kidney.