Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evidence for Effects of Chronic Lead Exposure on Blood Pressure in Experimental Animals: An Overview.
Author Victery, W. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Year Published 1988
Report Number EPA/600/D-88/018;
Stock Number PB88-170097
Additional Subjects Lead(Metal) ; Blood pressure ; Reviews ; Exposure ; Hypertension ; Models ; Toxicology ; Laboratory animals ;
Library Call Number Additional Info Location Last
NTIS  PB88-170097 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 18p
Information obtained in a number of experimental studies conducted over the last forty years on the effects of lead on blood pressure is reviewed. Differences in animal species, age at beginning of exposure, level of lead exposure, indices of lead burden, and blood pressure effects of each study are reported. In several of the high-dose experiments, hypertension was observed, but nephrotoxicity of lead may have contributed to its development. Moreover, in other high-dose experiments, no hypertension was observed and in at least one, the evidence suggested that lead could reduce an elevated blood pressure. In contrast, the lower-dose experiments consistently demonstrated a hypertensive effect. Overall, the data suggest a biphasic dose response.