Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title DNA Adduct Formation by 12 Chemicals with Populations Potentially Suitable for Molecular Epidemiological Studies.
Author Uziel, M. ; Munro, N. B. ; Katz, D. S. ; Vo-Dinh, T. ; Zeighami, E. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Oak Ridge National Lab., TN. Health and Safety Research Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/321;
Stock Number PB92-227628
Additional Subjects DNA adducts ; Mutagens ; Confounding factors ; Epidemiology ; Metabolism ; Absorption ; Carcinogens ; DNA damage ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-227628 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/01/1993
Collation 58p
DNA adduct formation, route of absorption, metabolism and chemistry of 12 hazardous chemicals are reviewed. Methods for adduct detection are also reviewed and approaches to sensitivity and specificity are identified. The selection of these 12 chemicals from the Environmental Protection Agency list of genotoxic chemicals was based on the availability of information and on the availability of populations potentially suitable for molecular epidemiological study. The 12 chemicals include ethylene oxide, styrene, vinylchloride, epichlorohydrin, propylene oxide, 4,4'-methylenebis-2-chloroaniline, benzidine, benzidine dyes (Direct Blue 6, Direct Black 38 and Direct Brown 95), acrylonitrile and benzyl chloride. While some of these chemicals (styrene and benzyl chloride, possibly Direct Blue 6) give rise to unique DNA adducts, others do not. Potentially confounding factors include mixed exposures in the work place, as well the formation of common DNA adducts. Additional research needs are identified. (Copyright (c) 1992 Elsevier Science Publishers B.V.)