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RECORD NUMBER: 1 OF 8

OLS Field Name OLS Field Data
Main Title Comparative Tumor-Initiating Activity of Complex Mixtures from Environmental Particulate Emissions on SENCAR Mouse Skin.
Author Newnow, S. ; Triplett, L. L. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA-600/J-81-343;
Stock Number PB84-171222
Additional Subjects Neoplasms ; Toxicology ; Pathology ; Mice ; Laboratory animals ; Skin(Anatomy) ; Reprints ; Air pollution effects(Animals) ; Particulates
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB84-171222 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract
The value of the SENCAR mouse for testing tumorigenic properties of complex mixtures on mouse skin was studied. Seven complex mixtures were obtained as dichloromethane extracts of collected particulate emissions from three diesel-fueled automobiles, a heavy-duty diesel engine, a nonleaded gasoline-fueled automobile, a coke oven battery, and a roofing tar pot. These emissions were applied topically at multiple doses to both male and female SENCAR mice that were subsequently promoted with 12-0-tetradecanoylphorbol 13-acetate. Two statistical analyses were applied to the data to rank the samples and to provide 95% confidence intervals.