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RECORD NUMBER: 21 OF 25

OLS Field Name OLS Field Data
Main Title Reference Physiological Parameters in Pharmacokinetic Modeling.
Author Arms, A. D. ; Travis, C. C. ;
CORP Author Oak Ridge National Lab., TN.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Year Published 1988
Stock Number PB88-196019
Additional Subjects Physiological effects ; Risk ; Chemical compounds ; Pharmacology ; Drugs ; Physiology ; Mice ; Rats ; Humans ; Exposure ; Metabolism ; Respiration ; Biochemistry ; Pharmacokinetics
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB88-196019 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 112p
Abstract
The document presents a compilation of measured values for physiological parameters used in pharmacokinetic modeling. The physiological parameters include body weight, tissue volumes, cardiac output distribution, and respiration parameters. Reference values for use in risk assessment are given for each of the physiological parameters based on analyses of valid measurements obtained from the literature and other reliable sources. The proposed reference values are for generic mice and rats without regard to sex or strain. Reference values for humans are without regard to age or sex. Differences between the sexes in mice, rats, and humans are accounted for by scaling the reference parameters within species on the basis of body weight. Reference physiological parameters are for a 0.025 kg mouse, 0.25 kg rat, and a 70 kg man.