Main Title |
Effect of Ozone on Human Cellular and Humoral Immunity: Characterization of T and B Lymphocytes by Rosette Formation. |
Author |
Savino, Anthony ;
Peterson, Marzda L. ;
House, Dennis ;
Turner, Alvis G. ;
Jeffries., Harvey E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div. |
Year Published |
1978 |
Report Number |
EPA/600/J-78-026; |
Stock Number |
PB-284 383 |
Additional Subjects |
Ozone ;
Lymphocytes ;
Blood cells ;
Immunity ;
Toxicology ;
Exposure ;
Humans ;
Experimental data ;
Erythrocytes ;
Tables(Data) ;
Males ;
Reprints ;
Toxic substances ;
B lymphocytes ;
T lymphocytes ;
Rosette formation ;
Humoraral immunity ;
Cellular immunity ;
Air pollution effects(Humans)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-284 383 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Eight healthy male subjects were exposed to 784 micrograms cu m (0.4 ppm) of ozone for 4 hours in an environmentally controlled exposure chamber. Peripheral blood samples were taken before and after air and ozone exposures and again at 72 hours and 2 weeks. These blood samples were examined for the percentages of rosette-forming T and B lymphocytes. No statistically significant depressions in T-lymphocyte rosette formation with sheep erythrocytes were found following exposure to air or ozone. The ability of B lymphocytes to form rosettes with sensitized human erythrocytes was depressed following ozone exposure. These results suggest that surface receptors and/or cell membranes of peripheral blood B lymphocytes may be temporarily altered following short-term exposure to ozone. |