Record Display for the EPA National Library Catalog

RECORD NUMBER: 483 OF 527

OLS Field Name OLS Field Data
Main Title Toxicology of Abate in Laboratory Animals.
Author Gaines, Thomas B. ; Kimbrough, Ranate ; Laws, Jr., Edward R. ;
CORP Author National Communicable Disease Center, Atlanta, Ga.
Year Published 1966
Stock Number PB-279 276
Additional Subjects Pesticides ; Toxicology ; Bioassay ; Dogs ; Insecticides ; Cholinesterase inhibitors ; Phosphorus organic compounds ; Lethal dosage ; Rats ; Laboratory animals ; Dosage ; Toxicity ; Concentration(Composition) ; Ingestion(Biology) ; Mice ; Rats ; Rabbits ; Signs and symptoms ; Chickens ; Reproduction(Biology) ; Reprints ; Abate ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-279 276 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 6p
Abstract
In laboratory animals Abate produces signs, symptoms, and type of death typical of those associated with other organic phosphorus compounds. In large enough doses Abate will inhibit cholinesterase, and it does this more promptly and to a greater extent for RBC cholinesterase than for plasma cholinesterase. The acute oral lethal dose (LD50) for Abate in rats and male mice is 4,000 mg/kg or greater. Restrained female rats tolerate a dermal dose of Abate of 4,000 mg/kg without clinical effect, but the same dosage killed two of ten males. Rats, rabbits, guinea pigs, and chickens tolerate a daily oral dosage of Abate of 10 mg/kg without observable clinical effect, and dogs tolerate a daily dosage of 3 to 4 mg/kg, the highest rate at which they were dosed. Rats and rabbits tolerate at a dosage of 1 mg/kg/day for extended periods of time without detectable effect on cholinesterase.