In laboratory animals Abate produces signs, symptoms, and type of death typical of those associated with other organic phosphorus compounds. In large enough doses Abate will inhibit cholinesterase, and it does this more promptly and to a greater extent for RBC cholinesterase than for plasma cholinesterase. The acute oral lethal dose (LD50) for Abate in rats and male mice is 4,000 mg/kg or greater. Restrained female rats tolerate a dermal dose of Abate of 4,000 mg/kg without clinical effect, but the same dosage killed two of ten males. Rats, rabbits, guinea pigs, and chickens tolerate a daily oral dosage of Abate of 10 mg/kg without observable clinical effect, and dogs tolerate a daily dosage of 3 to 4 mg/kg, the highest rate at which they were dosed. Rats and rabbits tolerate at a dosage of 1 mg/kg/day for extended periods of time without detectable effect on cholinesterase.