Main Title |
Comparative methylation chemistry of platinum, palladium, lead, and manganese / |
Author |
Taylor, Robert Thomas,
|
CORP Author |
California Univ., Livermore. Lawrence Livermore Lab.;Health Effects Research Lab., Research Triangle Park, N.C. |
Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Available from the National Technical Information Service, |
Year Published |
1976 |
Report Number |
EPA/600-1-76-016 |
Stock Number |
PB-251 553 |
OCLC Number |
02668830 |
Additional Subjects |
Methylation ;
Platinum ;
Palladium ;
Lead(Metal) ;
Manganese ;
Air pollution ;
Fuel additives ;
Exhaust emissions ;
Concentration(Composition) ;
Toxicity ;
Tissue extracts ;
Biochemistry ;
Air pollution effects(Plants) ;
Air pollution effects(Humans) ;
Cobalamin/methyl
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-76-016 |
c.1 |
Headquarters Library/Washington,DC |
02/27/2014 |
EKBD |
EPA-600/1-76-016 |
|
Research Triangle Park Library/RTP, NC |
06/06/2003 |
ELBD ARCHIVE |
EPA 600-1-76-016 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
ELBD |
EPA 600-1-76-016 |
|
AWBERC Library/Cincinnati,OH |
08/26/2016 |
NTIS |
PB-251 553 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
vii, 26 pages : illustrations ; 27 cm. |
Abstract |
A study was carried out to evaluate the potential for platinum, palladium, lead, and manganese salts and oxides to be biochemically methylated. Methylation is an important, well recognized, determinant of metal toxicity; the striking example being the extreme health hazard of methylated mercury. The possible biological methylation of the metals which are associated with emissions arising from the use of automotive fuels, fuel additives, and catalytic control devices is of special concern to the Environmental Protection Agency's Catalyst Research Program. Salts of platinum, palladium, and lead, and oxides of lead all containing the metal in a +4 valence were observed to demethylate methylcobalamin, a biologically active form of vitamin B-12. Inorganic salts and oxides of manganese were unreactive. No evidence for a stable monomethyl-metal derivative was found using palladium and lead compounds as reactants. However, salts of platinum +4 do result in the formation of stable methylation products. The reaction product formed from methylcobalamin and hexachloroplatinate was shown definitively to be a monomethyl-platinum compound. It is sufficiently stable in aqueous solutions under a variety of conditions to exist in freshwater ecosystems and to exhibit toxic effects on mammalian cells. |
Notes |
"EPA/600-1-76-016." "March 1976." |