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RECORD NUMBER: 1 OF 1

OLS Field Name OLS Field Data
Main Title Susceptibility to Atherosclerosis in Aortas and Coronary Arteries of Swine with von Willebrand's Disease.
Author Griggs, Thomas R. ; Reddick, Robert L. ; Sultzer, David ; Brinkhous, K. M. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD.
Year Published 1980
Report Number EPA-R-804959 ;N01-HL0-1648; EPA-600/J-81-585;
Stock Number PB83-145250
Additional Subjects Arteriosclerosis ; Arteries ; Cardiovascular diseases ; Diets ; Swine ; Tolerances(Physiology) ; Aorta ; Reprints ; Von Willebrands disease
Holdings
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Status
NTIS  PB83-145250 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 11p
Abstract
The development of coronary and aortic atherosclerosis was determined after balloon catheter injury of coronary arteries and administration of an atherogenic diet in normal pigs and pigs that were homozygous and heterozygous for von Willebrand's disease. Coronary atherosclerosis developed to a similar degree in all three phenotypic groups. The difference between the aortic lesions of normal animals and bleeders was significant. Absence of von Willebrand factor was associated with limited resistance to atherosclerosis in the aortas of experimental pigs but did not affect the development of atherosclerosis in either ballooned or nonballooned coronary arteries. These findings suggest, first, that von Willebrand factor function is not essential to the development of the atherosclerotic lesion in this model and, second, that the role of the von Willebrand factor in the development of atherosclerosis is complicated and appears to involve interaction with variables not yet defined.