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OLS Field Name OLS Field Data
Main Title Lack of Effect of Drinking Water Barium on Cardiovascular Risk Factors.
Author Wones, R. G. ; Stadler, B. L. ; Frohman., L. A. ;
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/120;
Stock Number PB91-109595
Additional Subjects Barium ; Potable water ; Cardiovascular diseases ; Risk ; Communities ; Tests ; Males ; Dosage ; Diets ; Cholesterol ; Fats ; Carbohydrates ; Proteins ; Sodium ; Potassium ; Electrocardiography ; Reprints ; Drinking water
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-109595 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 7p
Abstract
Higher cardiovascular mortality has been associated in a single epidemiological study with higher levels of barium in drinking water. The purpose of the study was to determine whether drinking water barium at levels found in some U.S. communities alters the known risk factors for cardiovascular disease. Eleven healthy men completed a 10-week dose-response protocol in which diet was controlled (600 mg cholesterol; 40% fat, 40% carbohydrate, 20% protein; sodium and potassium controlled at the subject's pre-protocol estimated intake). Other aspects of the subjects' lifestyles known to affect cardiac risk factors were controlled, and the barium content (as barium chloride) of the drinking water (1.5 L/day) was varied from 0 (first 2 weeks), to 5 ppm (next 4 weeks), to 10 ppm (last 4 weeks). Multiple blood and urine samples, morning and evening blood pressure measurements, and 48-hr electrocardiographic monitoring were performed at each dose of barium. There were no changes in morning or evening systolic or diastolic blood pressures, plasma cholesterol or lipoprotein or apolipoprotein levels, serum potassium or glucose levels, or urine catecholamine levels. There were no arrythmias related to barium exposure detected on continuous electrocardiographic monitoring. A trend was seen toward increased total serum calcium levels with exposure to barium, which was of borderline statistical significance and of doubtful clinical significance. In summary, drinking water barium at levels of 5 and 10 ppm did not appear to affect any of the known modifiable cardiovascular risk factors.