||Is Delayed Neurotoxicity a Property of all Organophosphorus Compounds. A Study with a Model Compound: Parathion.
Soliman, Salah A. ;
Farmer, Jackie ;
Curley, August ;
||Health Effects Research Lab., Research Triangle Park, NC.
Phosphorus organic compounds ;
Laboratory animals ;
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A recently reported hypothesis of other investigators that the induction of delayed neurotoxicity is a property of all organophosphorus compounds including parathion was evaluated in light of the inability of parathion to induce in the laboratory any clinical, histological, or biochemical signs of delayed neurotoxicity in hens following a very intensive dosing regimen. Parathion was administered orally or applied dermally as 1 mg/kg/day for 1 week and then the dose was increased by 1 mg/kg/day at weekly intervals up to 6 mg/kg/day which was given thereafter until a total of 90 doses. Results indicate that parthion either orally or dermally did not produce delayed neurotoxicity in hens comparable to that induced by tri-orthocresyl phosphate (TOCP) in this experiment.